PSYC 301 Study Guide - Midterm Guide: Selective Serotonin Reuptake Inhibitor, Dorsolateral Prefrontal Cortex, Substantia Nigra
22 Apr 2016
School
Department
Course
Professor
Document Summary
Synapse and components: synapse influx of ca2+ drives chemical events that cause synaptic vesicles to move to terminals, synaptic vesicles packages of neurotransmitters. Neurotransmitters synthesized in cytoplasm of synaptic terminals and packaged in golgi. Kiss & run > recycling pool are closest to memb, resting pool behind. Binding proteins help move to pre-synaptic membrane. Exocytosis neurotransmitter release: result of ap that triggers ca2+ ions into presynaptic membrane. Ionotropic receptors associated with ligand-activated ion channels (ex. Acetylcholine: neurotransmitter binds to receptors on ion channels, channel opens or closes, altering flow of ions into or out of neuron. Reuptake transporter transports back to presynaptic neuron and ach reformed. Ache inhibitors poisons, stop it from being broken down and ach will. Ionotropic vs. metabotropic keep binding to receptors: iono = faster, less room for error, meta = cause cascade that amplifies effects/rxns. Synaptic homeostasis: autoreceptors in presynaptic membrane, stimulated when ^ nt in cleft.
