PMY 302 Study Guide - Midterm Guide: Renin Inhibitor, Nonsteroidal Anti-Inflammatory Drug, Drug Interaction
17 May 2016
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Heart failure, two types of hf, left ventricle systolic dysfunction (focused tx) 7: pathophysiology of hf, cardiac remodeling, physiologic adaptations to reduced cardiac output (co) Natriuretic peptides (discharge na+ from urine: diuretics, thiazide diuretics, high-ceiling (loop) diuretics, potassium-sparing diuretics, captopril, inhibit raas - ace inhibitor, hemodynamic benefits. Suppression of aldosterone release: impact on cardiac remodeling - ace inhibitors have favorable impact, adverse effects, hypotension, hyperkalemia. Intractable cough: angioedema, renal failure if patient has bilateral renal artery stenosis. Bradycardia or heart block: digoxin and cardiac glycosides (2nd line agents) Positive inotropic actions (don"t help with life expectancy) Favorably affect neurohormonal systems: inotropic agents, sympathomimetics. Dp activates beta 1 receptors in the heart, kidneys, bv. Dobutamine synthetic catecholamine selective activation of beta 1 receptor: phosphodiesterase inhibitors. Positive inotropic action on the heart, increases the force of ventricular contraction. Relationship of potassium to inotropic action, k+ levels must be kept in normal physiologic range. Hemodynamic benefits, increased co & urine production.
