BSC 450- Final Exam Guide - Comprehensive Notes for the exam ( 65 pages long!)
29 Mar 2018
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Water surrounding nonpolar solutes has lower entropy: van der waals are everywhere, g = h - t s. Multiple weak interactions act additively: release of ordered water favors formation of an enzyme substrate complex. While separate, both enzyme and substrate force neighboring water molecules into an ordered shall. Binding of substrate to enzyme releases some of the ordered water and the resulting increase provides a thermodynamic push toward formation of the enzyme substrate complex ph, pka and buffers. Ionization of water: h2o h+ + oh- Keq for ionization of water: h2o h+ + oh, keq = [h+] [oh-] / [h2o] = 1. 8 x 10-6 m. [h2o] = (1000g / 18. 015g/mol) / 1l = 55. 5m. [h+] [oh-} = keq x [h2o] = 1 x 10-14 m2 = kw. In pure water [h+] = [oh-] = 10-7 m. This relationship defines ph: ph = -log[h+, kw = [h+] [oh-] = 1 x 10-14 m2, log [h+]] + log [oh-] = -14.
