CHEM 3310 Study Guide - Final Guide: Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase, Pyruvate Decarboxylase
Document Summary
*beware, this one has a lot of pictures! Video from the same group that did the amino acid video https://www. youtube. com/watch?v=1anotldesni: energy generation without an oxygen requirement, glucose biofuel prominence. Low-reactive ring-form minimizes protein glycosylation: 3 step process, 1: glucose trapping and destabilization (priming, 2: three carbon unit generation (cleaving, 3: energy generation, a lot of substrate level phosphorylation, (understand basic mechanisms) Ene intermediate: ring opened by base in enzyme, oh becomes new carbonyl. Base catalyzes ring closure again: phosphofructokinase (pfk): trapping the fructose isomer, mechanism is proximity and orientation, can"t really go back from this step (at least with this enzyme, glycolysis stage i, glucose trapping and destabilization (priming) Energy investment phase: glucose phosphorylated by kinase and then changed to fructose, which is phosphorylated again, uses 2 atp, 6c sugar cleaved to two 3c units, gap acceptable on test, 3pg might not be. *always number your carbons: aldolase reaction mechanism.
