PHR 4111 Study Guide - Final Guide: Cardiogenic Shock, Chronotropic, Inotrope

• School: St. John's University
• Department: PHR - PHARMACY - PHARMD
• Course: PHR 4111
• Professor: Zito, Barletta, Ceterra

Document Summary

Catecholamines positive inotropes with vascular e ects increase co. Pde inhibitors: inhibits pde that decreased camp -> increased ca. Pcwp; increased svr; bp adequate; low bp and decreased co. Increased contractility and hr -> o2 wasting and arrhythmia liability; dig does it with decreasing hr and saving o2. Direct acting on b1 but lacks beta oh. Low dose: inotropic action as beta 1 camp mediated increase in mc ca; chronotropic a1. Hypertension with beta agonists; hypotension with beta atangonists. Beta 1 positive inotrope and chronotrope; vd, but less than. Decreases after load (dose related), no change on map. Acls asystole, bradycardia, pea; pre-op to dry secretions. Inhibits breakdown of camp -> increased ca -> positive inotropic e ect. Decreases preload and after load by direct relaxation. Toxicity (claudius) dilated, blurry vision, dry skin, dry everything -> no speech, no bowel sounds, urinary retention, tachycardia, hyperthermia. Tachycardia; arrhythmia; myocardial ischmia hyperglycemia; extravasation at injection site; vf.