BIOL 469 Study Guide - Midterm Guide: Follistatin, Kainic Acid, Tropomyosin Receptor Kinase B
LECTURE 22 → GLIA
➢What are the main glial cell types in the PNS and CNS and what are their developmental
origins?
➢Which glial cell type (s)
• is derived from bone marrow?
• implicated in regulation of the BBB?
• is involved in the production of CSF?
• involved in reuptake of classical neurotransmitters?
• is the principal source of cytokines released in response to injury?
• responds to proinflammatory cytokines ?
• form glial scars in response to injury?
• Are part of the CNS? PNS?
➢What are the developmental origins of different glial cells ( Neural tube vs neural crest vs
yolk sac?)
➢Compare and contrast Schwann cells and oligodendrocytes.
➢What are the principal proteins present in myelin produced by Schwann cells and
oligodendrocytes?
➢Which diseases of the nervous system affecting primarily myelination of peripheral and
central nerves, respectively can you think of? And what proteins are primarily affected?
(I suggest you make a table)
➢Given that glial cells can uptake and release neurotransmitters and express
neurotransmitter receptors, what distinctive feature(s) of neurons do they lack?
LECTURE 23 → NT RELEASE
➢What is the purpose of using TTX when analyzing mechanisms of vesicle release?
➢What evidence is there that vesicle release is triggered by Ca2+ entry into synaptic terminals
(rather than any other ion) ?
➢What drugs or salts can be used to block Na+ or K+ channels?
➢What are the properties of Ca2+ that render it ideal as a mediator of incredibly fast
biochemical reactions?
➢Compare and contrast V-gated K+, Na+ and Ca2+ channels. Which pair is most similar
➢V-gated Ca2+ channels occur not only at synaptic terminals but also on dendrites. How do
they differ, or how can you distinguish them
➢What is a quantum of NT? And how does it related to a miniature postsynaptic potentials.
Document Summary
What are the developmental origins of different glial cells ( neural tube vs neural crest vs yolk sac?) Compare and contrast schwann cells and oligodendrocytes. And what proteins are primarily affected? (i suggest you make a table) What are the properties of ca 2+ that render it ideal as a mediator of incredibly fast. Compare and contrast v-gated k+, na+ and ca2+ channels. V-gated ca2+ channels occur not only at synaptic terminals but also on dendrites. How do they differ, or how can you distinguish them. And how does it related to a miniature postsynaptic potentials. Compare and contrast three different mechanisms of membrane retrieval from synaptic terminals. Name two methods used to measure the release of nt. What are the limitations of these techniques (why can they not be used to measure release of glutamate, gaba, glycine) What are the seven steps of the nt release cycle.
