B M B 211 Midterm: BMB 211 – Exam 2 Notes
3 Dec 2016
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Document Summary
Leucine zipper: most site recognition in the major groove. Neural retina leucine zipper: critical intrinsic regulator of photoceptor development and function, mutations of this gene have been linked to retinal degeneration, failure to develop the retina. X-ray crystallography: used to obtain 3-dimensional structural information about proteins. Protein structure & function importance: implications for drug design. Blast cell primitive undifferentiated blood cell: abl kinase inhibitor resulted in the death of cml cells with few side effects stream. Fibronectin structure: mosaic or modular proteins consist of repeated domains, fibronectin has 3 repeated domains (f1, f2, f3) Domain modules are coded for by genetic sequenced created by gene. Tertiary structure duplications: 3 dimensional structure from the folding and covalent cross linking of a protein or polynucleotide molecule, hydrophobic interactions, electrostatic interactions (salt bridges), h+ bonds, covalent bonds, and hydration. Allosteric transition can change protein conformation and function. Ligands triggering the transitions are effectors and modulators.
