MOLGEN 4500 Midterm: MOLGEN 4500 Module 1 & 2

• School: Ohio State University
• Department: Molecular Genetics
• Course: MOLGEN 4500
• Professor: All

Document Summary

Question 1: compare and contrast mendel"s principle of segregation and the principle of independent assortment. Segregation: chromosomes separate during meiosis i, separating the alleles on the homologous chromosomes. Independent assortment: sister chromatids during meiosis ii, sorting the alleles of the chromosome into different gamete cells. Question 2: suppose you repeated thomas morgan"s experiments by crossing drosophila females of wild type red eye appearance and normal wing length with males showing two autosomal recessive traits: purple eyes and vestigial wings. From inspection, this ratio easily deviates from the 1:1:1:1 mendelian ratio expected for a testcross. We see that the wild type and double recessive offspring are the largest phenotypic classes, while the other two classes are fewer, a characteristic of recombination resulting in recombinant offspring. It points to close linkage between the two genes. Question 3: describe the difference between homologous chromosomes and sister chromatids.