MOLGEN 4500 Midterm: MOLGEN 4500 Midterm 1 Notes
5 Oct 2018
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The sister chromatids of each chromosome, however, remain attached to one another and don"t come apart: telophase 1: chromosomes arrive at opposite poles of the cell. Spermatocyte (haploid) (meiosis 2) spermatids (haploid) (differentiation) . Spermatozoa (haploid: nondisjunction: separation of chromatids fails to occur; can happen in meiosis 1 or 2; abnormal gametes produced, results in aneuploidy: a condition in which the chromosome number is not an exact multiple of the haploid set. Individuals with affected sib has 25% chance of being affected. If both parents are carriers, then there is only a 25% chance they will have an affected child: cystic fibrosis, phenylketonuria, autosomal dominant traits: In males, whatever alleles are on the x are expressed: males are neither homozygous nor heterozygous for x-linked genes, they are hemizygous for these x-linked genes. Identified in pedigrees: all sons exhibit mutant trait of mother: ex: color blindness, hemophilia a,b, duchenne muscular dystrophy.
