PHSC 4340 Midterm: exam 2

• School: Northeastern University
• Department: Pharmaceutical Science
• Course: PHSC 4340
• Professor: Norman Biosse

Document Summary

Acetylcholine sweat glands and skeletal muscle blood vessels. Alpha 1, alpha 2, beta 1, beta 2. Relevant cholinergic drugs and their modes of action. Anticholinesterases prevent the breakdown of ach into choline and acetate. Muscarinic agonists mimic muscarinic effects of ach. Muscarinic antagonists block responses mediated by muscarinic receptors. Nicotinic agonists mimic nicotinic effects of ach. Nicotinic antagonists block major ganglionic transmission or neuromuscular transmission in skeletal muscles. Beta 1 heart and kidney (1 heart, beta 1) Beta 2 lungs and veins (2 lungs, beta 2) Norepinephrine effect on heart through beta 1 receptors. Adrenergic receptors cause slow signaling like muscarinic ach receptors. Multiple steps involved but beta 1 receptor activation leads to an increase in ca release inside the heart muscle, causing increased contraction. Also increases heart rate and speed of conduction. Relevant adrenergic drugs and their modes of action. Mao inhibitors increase ne in vesicles (ex: selegiline) Catecholamine pump inhibitors increases ne in synaptic cleft (ex: antidepressants, cocaine)