BIOL 3409 Study Guide - Midterm Guide: Megakaryocyte, Tumor Suppressor Gene, Breast Cancer
9 Sep 2017
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Lecture 10 tumor suppressor genes p53. Tumor suppressors: sv40 t-antigen binds to prb and inactivates it, prb (hypophosphorylated) = target for tumor viruses. P53 increase highest affinity sites will be occupied first lower affinity sites eventually occupied later: mdm2 tightly regulated, arf - product of alternative splicing = negative regulator. Under control of e2f = positive regulator of transcription (active recruits acetylases and makes dna available: high levels of e2f push through cell cycle higher levels of arf binds. Narrow range of cell size before flooding nucleus with e2f. Flood nucleus with e2f larger range of cell size. Cells now undergoing apoptosis (shrinkage, membrane shedding: p53 overexpression, fewer tumors, accelerated aging, diminished ability to replenish cells, p53 expression increases in sv40 transformed cells, contain mutant p53. Don"t want to release contents of cells and expose surrounding cells and tissue. Inflammation, immune system, brain damage, swelling etc: natural (not pathological) event.
