CHE 211 Study Guide - Final Guide: Carbohydrate, Nicotinamide Adenine Dinucleotide, Pyruvic Acid

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9 May 2018
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Organic Chemistry 2: Carbohydrate Metabolism
Glycolysis
Embden-Meyerhof Pathway
Glycolysis:
o Glycolysis is the metabolic by which glucose (6-Carbon molecule is converted
into 2 molecules of pyruvate (3-Carbon molecule); this anaerobic process yields a
net energy molecules of ATP and 2 molecules of NADH; this metabolic process
functions in all cells
o The conversion of glucose to pyruvate is an oxidative process in which no
molecular molecule of oxygen is utilized; metabolic pathways in which molecular
oxygen is not a participant are called ANAEROBIC pathways; metabolic pathways
in which oxygen is used are called AEROBIC pathways
o Glycolysis is an ANAEROBIC pathway
o Pathway for carbohydrate catabolism
o Begins with D-glucose as the substrate
o All organisms can use glucose as an energy source
o Requires no oxygen
o Occurs free in the cytoplasm
o Glycolysis is a ten step pathway, where each step is catalyzed by different
enzymes
Products:
Substrate-level phosphorylation gives 4 ATP
A phosphoryl group is transferred to ADP from 1,3- bisphosphoglycerate
and phosphoenolpyruvate
NADH carries hydride anions with two electrons
Pyruvate: the fate depends on cellular conditions
Overall, the products of glycolysis include chemical energy in the form of ATP,
chemical energy in the form of NADH, and 2 molecules of pyruvate
The steps of glycolysis along with the 3 major products of glycolysis can be seen
in the next slide
Summary of Glycolysis Reactions
This figure is 21.6 and it summarizes the 10 steps of glycolysis
The 3 major product of glycolysis are: ATP (chemical energy), NADH (chemical energy)
and pyruvate (2 molecules, both 3-carbon)
4 molecules of ATP are formed through the process known as substrate level
phosphorylation production of ATP by the transfer of the phosphoryl group from the
substrate of the reaction to a molecule of ADP; even though a total of 4 ATP molecules
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Document Summary

Products: substrate-level phosphorylation gives 4 atp. This figure is 21. 6 and it summarizes the 10 steps of glycolysis. The 3 major product of glycolysis are: atp (chemical energy), nadh (chemical energy) and pyruvate (2 molecules, both 3-carbon) The 2 atp molecules synthesized during glycolysis represents 2. 2% of the potential energy of glucose this means that glycolysis is not a very efficient at harvesting energy. Nad+ is reduced to nadh during step 6 of glycolysis, which is where glyceraldehyde-3- phosphate is oxidized; under anaerobic nadh is used as a source of electrons in the fermentation reactions. The last 2 products (nadh and pyruvate) must be used in some way or the process of glycolysis would stop; if the concentrations of pyruvate gets too high, the process of glycolysis would stop. Glycolysis can be divided up to 2 segments. The first segment is the investment of energy, which includes the first five steps of the reaction.

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