MBI 131 Study Guide - Midterm Guide: Nicotine, Fetal Alcohol Spectrum Disorder, Drug Policy Of Oregon

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Communicable Diseases: Pg. 108-111

Infectivity: ability of a biological agent to enter and grow in the host

Pathogenicity: the capability of a communicable disease agent to cause disease in a

susceptible host

Under certain conditions, pathogenic biological agents can be transmitted from an

infected individual in the community to an uninfected, susceptible one

Communicable disease model: the minimal requirements for the occurrence and spread

of communicable diseases in a population—agent, host and environment

Agent: element that must be present for disease to occur

oEx: influenza virus must be present for a person to become ill

Host: any susceptible organism invaded by an infectious agent

Environment: all other factors (physical, biological, social)

Chain of infection

oPathogenic agent leaves its reservoir via a portal of exit

oTransmission occurs in a direct or indirect manner

oPathogenic agent enters a susceptible host through a portal of entry to establish

infection

oReservoir for a disease may be a case (person who has the disease) or a carrier

(one who is well but is infected and is capable of serving as a source of infection)

oZoonoses: diseases for which the reservoir resides in animal populations

oAnthroponoses: diseases for which the reservoir is the human population

Modes of transmission

oDirect transmission: immediate transfer of the disease agent between the

infected and susceptible individuals by direct contact

Ex: AIDS, syphilis, gonorrhea, rabies and the common cold

oIndirect transmission

Airborne: dissemination of microbial aerosols to a suitable port of entry

Microbial aerosols are suspensions of droplet nuclei made up wholly or in

part of microorganisms

Vehicleborne: contaminated materials serve as vehicles (nonliving objects

by which communicable agents are transferred to a susceptible host)

Vectorborne: transfer of a disease by a living organism such a vector( a

living organism, usually an arthropod) that can transmit a communicable

agent to susceptible hosts

Biological: multiplication or developmental changes of the disease agent

occur in the vector before transmission occurs

Prevention of Communicable Diseases: Pg. 117-124

Prevention: planning for and taking action to prevent or forestall the occurrence of an

undesirable event (more desirable than intervention)

Control: general term for containment of a disease, includes prevention and

intervention measures

Eradication: the complete elimination or uprooting of a disease

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Document Summary

Infectivity: ability of a biological agent to enter and grow in the host. Pathogenicity: the capability of a communicable disease agent to cause disease in a susceptible host. Under certain conditions, pathogenic biological agents can be transmitted from an infected individual in the community to an uninfected, susceptible one. Communicable disease model: the minimal requirements for the occurrence and spread of communicable diseases in a population agent, host and environment. Agent: element that must be present for disease to occur: ex: influenza virus must be present for a person to become ill. Host: any susceptible organism invaded by an infectious agent. Modes of transmission: direct transmission: immediate transfer of the disease agent between the infected and susceptible individuals by direct contact. Ex: aids, syphilis, gonorrhea, rabies and the common cold: indirect transmission. Airborne: dissemination of microbial aerosols to a suitable port of entry. Microbial aerosols are suspensions of droplet nuclei made up wholly or in part of microorganisms.

Related Questions

For this assignment, Part One of your course project, assume the role of Dr. Madness. Your rogue nation seeks global domination. With a bare bones laboratory and your exhaustive microbiological and epidemiological knowledge, you (Dr. Madness) decide that the best way to rule the world is to create and disseminate the perfect biological weapon.

For this part of the assignment, you will develop your weapon from the ground up. Discuss nearly all of the epidemiological criteria related to it, and justify and discuss why it is used and how effective it is. This agent could be a hybrid of other biological pathogens or an entirely new one. If the agent is newly created, there must be some basis and epidemiological support of a similar agent by which you can base your justification. In other words, it will be unrealistic to create an airborne virus that inoculates and kills within one hour. There must be a realistic exposure and incubation time and must be supported through current agent biology or biochemistry (for example, influenza exposure and incubation takes 1â4 days).

Name of Agent: Explain why you chose the name. If it is a biological agent, be sure to provide a taxonomic name

Etiology: This will talk about the genesis of your agent. Where was it discovered? How was it made? How long has it been around? Why was this agent created? What were the social and economic factors of your rogue nation that made Dr. Madness focus on this element of the agent? What are the environmental precursors to this agent? Discuss the interaction among agent, host, and environment.

Identification: This will describe the basics of the agent. Is it a bacteria, virus, toxin, parasite, hybrid, or something else? Discuss how your agent presents within the human population. What are the symptoms in humans? What are the (zoonotic) symptoms in animals? How does the disease progress? Are there stages? Discuss the various stages including length of infection, severity, and the like. What are the diagnostic indicators? How would a doctor be able to identify this agent in a clinic or emergency room?

Laboratory Analysis: How will the agent be identified? Can it be grown in media? What type of laboratory methods can be used to identify the agent (microscopy, chromatography, PCR, and so on)?

Occurrence: This is the epi: who, what, when, where, how, and why of the disease. Where does it happen? When can it be found? Who is most and least susceptible to the agent (risk factors). More exotic and hard to find agents are harder to prevent and control but are also more difficult to initiate an epidemic or pandemic, whereas more generalized and known agents may be easier to cure, but have a much wider swath of causing pandemics. How do socioeconomic factors foster or inhibit the spread of disease?

Reservoir: What is the natural reservoir of the agent? Are there other organisms where this agent can reside without causing disease? Increasing the reservoir can enhance transmission but can also allow for easier identification and treatment in response to it.

Mode of Transmission: Consider inhalation, absorption, digestion, contact, and so forth. If you use multiple modes, justify your selections.

Incubation Period: Provide the range with an average (median) day of disease onset. Does the period change in different socioeconomic status identifiers (sex, age, race, creed, and so on)? Why or why not?

Period of communicability: How long is a person with this agent contagious? Increasing this period also increases the opportunity for study and thus treatment and control.

Susceptibility: Is the agent susceptible to reinfection of the same person? Allowing for this increases morbidity but usually mortality wanes in subsequent infections.

Taking on the role of Dr. Madness, generate your superweapon and describe the weapon using the above mentioned criteria. Remember, the focus in on creating something that becomes difficult to identify, monitor, or treat with prophylaxis. You will write out the proposal as Dr. Madness submitting this to his lead researcher to develop. This proposal should be approximately 6â8 pages in length, but some submissions may be longer.

Submit your Bioweapons and Epidemiology Part One proposal in the assignment area.

Please be sure to review the Bioweapons and Epidemiology Part One Scoring Guide for information on how this assignment is graded.

Project Requirements

To achieve a successful project experience and outcome, you are expected to meet the following requirements.

Written communication: Written communication is free of errors that detract from the overall message.

APA formatting: Resources and citations should be formatted according to current APA style and formatting.

Resources: Include all literature cited in the project.

Length of paper: 6â8 typed, single-spaced pages, not including cover page and resource list.

Font and font size: Arial, 10 point.

44.Charlotte touches a doorknob after an individual with MRSA touched the doorknob. Immediately after touching the knob, Charlotte scratches her leg and transmits some MRSA cells into a small wound.The doorknob is functioning as a(n) a. etiologic agent. c. mode of transmission. b. reservoir. d. host. 44.A man infected with a viral respiratory infection sneezes and releases tiny droplets containing viral particles. Two minutes later, a woman breathes in some of these tiny droplets and becomes infected by the same viral infection. The movement of this virus from one individual to another is best described as the a. etiologic agent. c. mode of transmission. b. reservoir. d. host. 45. Although sporadic outbreaks of measles occur in the United States, the disease is considered nonendemic. What differentiates measles from endemic diseases, such as chickenpox? a. Endemic diseases exhibit higher numbers of cases than a sporadic outbreak. b. Diseases that are not endemic lack a reservoir in the area. c. Endemic diseases do not exhibit sporadic outbreaks. d. Diseases that are not endemic remain in reservoirs without infecting humans. 46. Which of the following would indicate efforts to control a disease are working? a. The disease becomes endemic. b. The disease prevalence increases. c. The disease incidence decreases. d. Outbreaks of the disease only occur every other year. 47. Which of the following statements describes one of the three steps of surveillance used for infectious diseases? a. Patients with infectious diseases are required to be seen by a physician at the CDC. b. Physicians are required to submit all patient records electronically to the CDC for review. c. Patient charts are reviewed by an infection control practitioner when an infectious disease is suspected. d. Incidence data is collected in all cases of bacterial infections within the United States. 48. Which of the following lists correctly identifies nosocomial infections from most common to least common? a. urinary tract, pneumonia, septicemia b. pneumonia, urinary tract, surgical wounds c. septicemia, surgical wounds, diarrhea d. diarrhea, urinary tract, pneumonia 49. Mary, an elderly woman with an indwelling catheter, is admitted to a local hospital for treatment of pneumonia. Three days after her admission, Maryâs husband receives a call from the hospital. He is informed that Mary has a nosocomial infection. Which of the following statements is true? a. The nosocomial infection referred to is pneumonia. b. Mary has most likely developed a urinary tract infection. c. Of all hospital patients, 25â30% develop nosocomial infections. d. Maryâs nosocomial infection could have been prevented with improved ventilation. 50. A nurse working in a large hospital harbors MRSA as part of the normal microbiota in his nose. He is most likely the source of a MRSA outbreak if a. infected patients have all had been cared for by this nurse and the isolates are identical. b. the patients are all elderly and the isolates of MRSA are not genetically identical. c. all of the infected patients were seen by the same physician and half of the patients were cared for by this nurse. d. all of the infected patients are on the same floor of the hospital and all have a history of heart problems. 51. Which of the following is NOT an example of aseptic technique? a. use of antiseptic on skin prior to insertion of an IV line b. use of latex gloves during the insertion of an indwelling catheter c. disinfection of doorknobs and other inert surfaces d. use of trash can liners in all patient rooms 52. An individual case of diphtheria, a notifiable infectious disease, in a patient in Florida is confirmed by laboratory testing. This patientâs physician would be required to a. send a letter to the WHO in Geneva, Switzerland. b. contact the CDC in Atlanta, Georgia. c. treat the patient regardless of health insurance status. d. quarantine the patient for eight weeks. 53. Fifteen individuals within one province in China are diagnosed with SARS. Epidemiologists will most likely a. quarantine the entire province immediately. b. contact the CDC in the United States to see if any cases were reported in the United States. c. wait to see if more cases of SARS are reported. d. try to identify the index case. 54. How does vaccinating wild rodents or poultry influence human health? a. Vaccinating wild rodents or poultry has no effect on human health. b. Vaccinating wild rodents or poultry reduces transmission of zoonotic diseases to humans. c. Vaccinating wild rodents or poultry reduces the migration of microbes into temperate regions. d. Vaccinating wild rodents or poultry increases the emergence of drug-resistant bacteria. 55. Which of the following scenarios would help meet the goal of the One Health Initiative? a. vaccinating poultry against avian influenza to prevent influenza from being transmitted to humans b. taking steps to reduce carbon dioxide emissions to reduce the effects of climate change c. providing sanitation after flooding events to prevent gastrointestinal infections in humans d. increasing compliance during antibiotic treatment of tuberculosis patients to prevent emergence of drug-resistant strains of tuberculosis 56. If humans continue to develop rapid transportation systems into more parts of the world, we should expect to see a. pandemics tracing the path of the transportation systems. b. an increase in detection of blood-borne pathogens. c. a decrease in human encroachment into tropical rain forests. d. an increase in the spread of transmissible spongiform encephalopathies. 57. How has the AIDS pandemic influenced reemerging diseases? a. AIDS has increased the number of immunocompromised individuals who are susceptible to diseases that were previously declining in developed countries. b. AIDS has led to an increase in the number of disease vectors throughout the world. c. AIDS has increased the prevalence of protozoal and parasitic infections that were declining in underdeveloped countries. d. AIDS has caused evolution to occur in diseases that were close to being eradicated in all countries. 58. Which of the following is likely to occur as a result of climate change? a. Insect vectors will migrate from tropical regions to once-temperate regions. b. Gastrointestinal infections will decrease in tropical regions. c. Microbes currently found in temperate regions will move to tropical regions. d. Extreme weather will decrease and diseases will become less seasonal. 59. What features would allow a virus to be used effectively as a bioweapon? a. a high infectious dose c. person-to-person transmission b. transmission via an insect vector d. quick pathogen detection systems

Investigation of Possible Bioterrorism-Related Activity

Patient History:

A 38-year-old woman who resided in the Northeast was admitted to the hospital with fever, myalgia, and weakness, which progressed over 3 days to respiratory failure requiring mechanical ventilation. On day 22, after 3 weeks of intensive care, the patient was still febrile. Cultures of blood were negative.

Hospital personnel interviewed family members who reported no history of traditional risk factors for fever of unknown origin (e.g., relevant food, infected animal contact, or travel history). On day 24, the patient's family reported to hospital personnel that the patient's illness might have been caused by exposure to laboratory flasks and cultures kept in her apartment by her boyfriend. He was described as a foreign national studying biology, but recently he had returned to his country of citizenship. On day 25, the patient's family brought laboratory flasks, Petri dishes, and culture media to the hospital from the patient's apartment. Several contained an unidentified clear liquid. The patientâs unresponsiveness and the acknowledged potential for some bacterial species to be used as bioterrorist agents raised concerns among the infection control staff that this case might be associated with a bioterrorist event or unintentional exposure to contaminated materials in the patient's home. The hospital contacted local law enforcement, the Department of Public Health, and the Federal Bureau of Investigation about the unusual circumstances surrounding the case.

On day 30, under the authority of state communicable disease statutes and in cooperation with the local police department, fire department, and hazardous materials unit, NHDHHS personnel entered the patient's apartment to assess any possibility of an ongoing public health hazard. Remaining flasks were removed and cultured. After 48 hours, growth of a translucent, pinpoint, and smooth colony appeared on blood agar and chocolate agar.

Gram stain of the colonies revealed faintly staining Gram-negative rods that were catalase positive, oxidase positive, and rapidly urea positive. On day 33, the patient began to get better after extensive antibiotic therapy.

Early detection is essential to ensure a prompt response to a biological terrorist event. Local public health authorities must rely on clinicians to recognize and report suspicious or unusual presentations of disease. However, correlating suspicious cases originating from diverse locations or discerning an increase in common presentations above the normal baseline is difficult. As in this case, public health practitioners coordinating disease surveillance may be able to receive reports of rare diseases and to determine whether they are occurring at a higher than normal rate in a large surveillance area.

The CDC, in collaboration with local, state, and territorial health departments, is enhancing existing disease surveillance systems for specific diseases that are normally rare in the United States but thought to have a high potential for public health impact if used as biological terrorism agents. This is being accomplished by improving training of clinical, laboratory, and public health personnel in recognizing suspicious disease presentations and by expanding of existing, disease-specific surveillance infrastructure. In addition, surveillance is being improved for disease presentations, such as acute respiratory distress, hemorrhagic, or meningeal symptoms normally caused by common infectious agents, but that could indicate an increase in illnesses caused by a biological agent used in terrorism. Surveillance mechanisms to rapidly assess changes in rates of disease include monitoring of calls to local emergency medical systems, regularly reviewing emergency department discharge diagnoses, and linking infection control practitioner networks.

Assignment:

For this case study, write a 1-page report that describes the possible agent of bioterrorism along with pathogenesis, treatment, and prevention. Include a brief discussion of sentinel labs and their role in recognizing potential episodes of bioterrorism.

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MBI 131 Study Guide - Midterm Guide: Nicotine, Fetal Alcohol Spectrum Disorder, Drug Policy Of Oregon

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