PSYC 4035 : Neuropharmacology Study Guide
Document Summary
Ipsp (inhibitory postsynaptic potential) hyperpolarizing postsynaptic potentials drive membrane voltage from resting potential away from zero: epsp and ipsp caused by transmembrane ion currents (influx of na+, Ca++ produces epsps; influx of cl- produces ipsp, efflux of k+ produces. Ipsp: transmembrane currents are caused by increased conductance, which is caused by gating (opening and closing of ion channels) Increase diameter of neuron decreases internal resistance; less current lost across cell membrane: myelination increases membrane resistance to potassium, salutatory (dance) conduction signal boosted at node of ranvier (breaks in myelin sheath) Vesicular sequestration: vesicular transporters are antiporters (nt comes in for something to come out) energized by v- Adhd drugs (amphetamine, methylphenidate) stimulate norepinephrine system by stimulating release of nt. Suboxone is buprenorphine and naloxone, used to treat narcotic addiction, naloxone is intended to prevent iv injection (can"t get high by injection); buprenorphine is a partial mu agonist and a kappa antagonist.
