BIOL 4087 : BIOL 4087 Exam 3
Document Summary
Chapter 12: biosignaling: general features of signal transduction, g-protein coupled receptors, beta adrenergic receptor, receptor tyrosine kinases, insulin receptor, receptor guanylyl cyclase, oncogenes. G-protein coupled receptors: aka gpcr, 7tm, serpentine receptors, vary broad type of receptor, 1,000s of different kinds, fig. 12-13: different types of gpcr, binding site on outside of membrane, structures are very similar, beta- adrenergic receptor is activated by epinephrine, epinephrine binds, activates pathway, certain drugs that bind this pathway (fig. 12-3: beta adrenergic receptor, ligand epinephrine, fig. Inactive form is with gdp bound: alpha subunit releases gdp and binds gtp, fig. 12-4b: 5) camp activates protein kinase a (pka, fig. 12-6a: pka has catalytic subunits and regulatory subunits, r subunits block active site of c subunits in inavtive form. 2: when camp binds to the r subunits, releasing the c subunits so they can phosphorylate, akap- a kinase anchoring protein, does something , see notebook, fig.
