CHEM 626 Study Guide - Midterm Guide: Halogenation, Alkylation, Acylation
Document Summary
Review sheet hour exam 2 charged aromatic compounds molecular orbitals (mos) Inscribed polygon (frost circle) method no f/c reactions on aniline (ph-nh2) polyhalogenation of strongly activated benzenes limitations on eas rxns. of substituted benzenes no f/c acylation on strongly deactivated benzenes. Eas reactions when two substituents are present benzylic bromination of alkyl benzenes oxidation of alkyl groups using kmno4. Clemmensen reduction of acyl groups:zn(hg) + hcl reduction of nitro groups using h2 and pd-c or sn/hcl. Chapter 17 benzene and aromatic compounds, continued aromatic compounds anti-aromatic compounds non-aromatic compounds. H ckel"s rule annulenes polycyclic aromatic hydrocarbons (pahs) aromatic heterocycles. Chapter 18 electrophilic aromatic substitution halogenation (bromination and chlorination) nitration sulfonation. Friedel-crafts acylation effect of substitutents on eas reactions inductive effects resonance effects activating vs. deactivating substituents ortho/para vs. meta directing substituents. Exam will cover: 17. 8-17. 10; 18. 1-18. 15; 19. 1-19. 3, 19. 7-19. 11, 19. 13, 19. 14; 20. 1-20. 5, 20. 6b-20. 7, 20. 9-20. 11.
