AN S 331 Study Guide - Midterm Guide: Protein Kinase C, Caspase, Glycoprotein
15 Apr 2017
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Many changes can occur during the peri-ovulatory period. When estrogen (estradiol) production by the granulosa cells of the antral follicle is. High - some estrogen re-enters the granulosa cells. This is coined as an autocrine effect. Estrogen binds to its nuclear (slow) receptor and acts locally to: Turn on genes for formation of lh (luteinizing hormone) receptors. Turn off genes for formation of fsh (follicle stimulating hormone) receptors. Inhibin blocks fsh release from anterior pituitary gland. We now have an ovulation-ready antral ready follicle. High levels of estrogen from ovulation-ready antral follicle cause systematic effects: Estrous behavior in females (if p4 [progesterone] levels are low) Gnrh surge from the hypothalamic surge center (if p4 levels are low) Leads to lh surge leads to ovulation. Lh ( released during surge) binds to: Turns on enzyme complex #1 and #2. Luteinization : change of steroidogenic activity to progesterone p4.
