Chemistry 27 Midterm: CHEM27 Harvard Exam2 2004key
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Directions: do not write in red ink. You may use the back of this amino acid page for scratch work, but nothing written on this page will be graded: all intermediates must be drawn as a distinct step. You need not draw out proton: you should have 9 pages total. We have provided plenty of space for each answer. Solutions transfers as a distinct step: molecular model kits are permitted, a significant fraction of your exams are photocopied before they are returned. Chemistry 27 spring 2004 exam 2: (15 pts) the maximum length of solid-phase peptide synthesis is limited by the efficiency of each peptide addition reaction. Kent provided a way to overcome this length limitation by implementing a reaction that couples two synthetic peptides together, yielding a longer peptide composed entirely of native peptide bonds. This reaction is illustrated below by the coupling of two dipeptides, 1 and 2:
