NSCI 3032 Study Guide - Midterm Guide: Ketone, Boron, Diastereomer
6 Mar 2016
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Experiment 1 regioselective hydration of 1-hexene: 10 ml of 85% h2so4 followed by 5 ml of 1hexene. Purpose of acid is to break double bond and attach the hso4 unit to the chain: stir the mixture for 15 min using a magnetic stirrer. The reaction is mildly exothermic and the mixture gradually becomes homogeneous: add another 5 ml of 1-hexene, stir the mixture for a further 10 min. Adding hexane in 2 steps as to not overheat the reaction: add contents of flask to a rb flask with 20ml of tap water. The mixture in the rb flask should consist of two layers after you add the contents of the erlenmeyer flask. Using a boiling stick here bc the acid would dissolve the boiling stone. Water in the bottom and out the top: using a heating mantle attached to a voltage regulator, heat the contents of the rb flask to reflux for 5 min.
