NEUROSCI 223 Study Guide - Midterm Guide: Tubulin, Wild Type, Antibody

• School: Duke University
• Department: Neuroscience
• Course: NEUROSCI 223
• Professor: Nina Sherwood

Document Summary

Bio/neuro 223_spring 2016 key concepts lecture 3. Explain dynamic instability of microtubules catastrophe, rescue, mechanisms underlying each. Dynamic instability is the process in which mts are constantly growing or shrinking due to the stability and instability of tubulin. Alpha tublin does not hydrolyze gtp but only uses it for strcture. Gtp bound beta tubulin binds on the plus end of the. Mt and when it is hydrolyzed, the beta tubulin breaks off the plus end. The gtp cap is on the plus end and when gtp tubulin binds at a slower rate, the gtp cap begins to hydrolyze and that causes catastrophe. Be able to draw a basic schematic of microtubules, including +/- ends (i. e. how they"re/what makes them polar [and note what type of polarity we are referring to here]). Maps are microtubule associated proteins they alter the stability of growing/shrinking. Mts and are important in the regulation of mt growth.