NEUROSCI 223 Study Guide - Midterm Guide: Metaphase, Zygote, Gastrulation

• School: Duke University
• Department: Neuroscience
• Course: NEUROSCI 223
• Professor: Nina Sherwood

Document Summary

Central aim of neuroscience is to dissect the cellular and physiological underpinnings of behaviors, mental and cognitive activities. After early embryonic divisions, involution of a group of cells generates the three germ layers that will form the organisms. Totipotent- potential to develop into any cell type including the placenta (zygote) Pluripotent- potential to develop any cell type excluding the placenta. Have the potential to differentiate into many cell types. In early stages of development undergo symmetric divisions. Asymmetric distribution of fate determinants (proteins, dna/rna, organelles) into daughter cells- two cells with different fates: mechanisms of acd have been dissected in laboratory model systems other than humans. Thinking both in terms of the events that need to happen and how those events are regulated molecularly. Interphase: setting up axis of cell/ polarity by intrinsic or extrinsic cues. Pro-metaphase: fate determinants asymmetrically distributed within the cell. Metaphase: mitotic spindle orients to establish the division plane.