BIOL 1013 Study Guide - Fall 2018, Comprehensive Midterm Notes - Carbohydrate, Rna, Protein

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12 Oct 2018
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BIOL 1013
MIDTERM EXAM
STUDY GUIDE
Fall 2018
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Process of Science (Ch.1)
Driving Questions
How is the scientific method used to test hypotheses?
What factors influence the strength of scientific studies and whether the results of
any given study are applicable to a particular population?
How can you evaluate the evidence in media reports of scientific studies?
How does the scientific method apply in clinical trials designed to investigate
important issues in human health?
What is science?
A method to answer questions
A process of using observations and experiments to draw evidence-based
conclusions
A way of knowing
How do scientists draw conclusions?
Use best evidence available
Ask: Was the science performed properly?
Conclusions may be modified in the future
Science is a never-ending process
Make an observation
Start with an interesting, informal observation
Often unreliable, untested
Anecdotal evidence
Formulate a question
Use an observation to devise a question
Studying previous research
Read relevant literature
See current information on the subject of interest
Study peer-reviewed scientific literature
Peer Review : review of an article by experts before publication
Ensures that the authors have appropriately designed and interpreted their study
Weeds out sloppy research
Forming scientific hypotheses
Uses information to formulate a scientific hypothesis
A testable and falsifiable explanation for a scientific observation or question
Testable: supported or rejected by carefully designed experiments or
nonexperimental studies
Falsifiable: can be ruled out by data
Not all explanations are scientific hypotheses
An explanation that cannot be tested or refuted, falls outside the realm of
scientific explanation
A hypothesis is never proven
If false, it is rejected and no longer considered a possible answer to the original
question
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If the data support the hypothesis, it will be accepted until further testing and data
show otherwise
Experimentation
Hypotheses can be tested using experimentation
An experiment is a carefully designed test
The results of an experiment either support or rule out a hypothesis
Experimental group: experiences the experimental intervention or manipulation
Control group: experiences no experimental intervention or manipulation
Basis for comparison
The experimental group experiences the independent variable
That is, the factor being deliberately changed in the experimental group
The control group receives a placebo
A placebo is a fake treatment that mimics the experience of the experimental
groups
The dependent variable is the measured result of an experiment
Analyzed in both the experimental and control groups
Evidence based conclusions can be drawn from results
Drawing conclusions
Confidence in the conclusions drawn from experimentation is increased by the
repetition of the experiment by other scientists
Sample size is important
It is the number of experimental subjects or the number of times an
experiment is repeated
The larger the sample size, the more likely the results will have statistical
significance
Statistical significance is a measure of confidence that the results
obtained are “real” rather than due to random chance
Publication
Experimental results are published in peer reviewed journals
Drawing Conclusions 2
A hypothesis that continues to hold up after many years of rigorous testing may
eventually be considered a scientific theory
Finding patterns
Some questions cannot be tested through controlled experiments
Through careful observations or comparisons of phenomena in nature, scientists
can find patterns to help answer questions
Epidemiology is the study of patterns of disease in populations
Observing patterns can show a consistent relationship or link between variables
Correlation between two variables does not prove that one variable causes the
other
Correlation is not causation
Drawing Conclusions 2
Exercise caution when evaluating epidemiology results
Hard to control for complexity of a disease
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Document Summary

A process of using observations and experiments to draw evidence-based conclusions. Conclusions may be modified in the future. Use an observation to devise a question. See current information on the subject of interest. Peer review : review of an article by experts before publication. Ensures that the authors have appropriately designed and interpreted their study. Uses information to formulate a scientific hypothesis. A testable and falsifiable explanation for a scientific observation or question. Testable: supported or rejected by carefully designed experiments or nonexperimental studies. Falsifiable: can be ruled out by data. An explanation that cannot be tested or refuted, falls outside the realm of scientific explanation. If false, it is rejected and no longer considered a possible answer to the original question. If the data support the hypothesis, it will be accepted until further testing and data show otherwise. An experiment is a carefully designed test. The results of an experiment either support or rule out a hypothesis.

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