CAS BI 325 Study Guide - Final Guide: Radial Arm Maze, Radial Glial Cell, Morris Water Navigation Task
13 Mar 2018
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Chapters 23, 24 and 25: wiring, memory and plasticity (l 17-19, d 10. 1-4) Migrate: inside out ; first to dorsal vz as temporary subplate (innermost layer) > lvi > lv > liv > liii > lii (outermost layer) Differentiate: don"t wait for all neuronal layers to form; begins as soon as they reach and divide; programmed early (works in vitro) Ex/ reeler gene prevents neurons from migrating past subplate = developmental issues. Forming connections: growth cone, fasciculation via cams, guidance, ex1/ netrin gradient attracts toward ventral midline once reaches ventral midline, robo receptors upreg. Slit repels away: ex2/ chemoaffinity hypothesis: ephrins repel neurons away from posterior. (cid:1), axons from nasal retina to posterior tectum, Synapse formation: example at nmjs: temporal retina to anterior tectum (temporal axons have eph receptor) Activity-dependent cell death occurs: neurotrophins (ngf) promote survival of high-activity synapses by binding kinases and altering gene tx. High synaptic capacity early (infancy to puberty); major loss of synapses later (adolescence)
