NUR 311 Study Guide - Quiz Guide: Proton-Pump Inhibitor, Peptic Ulcer, Prostaglandin E1
Document Summary
Defensive factors protects stomach and duodenum. Bicarbonate: secreted by epithelial cells and duodenum. Prostaglandins: stimulate secretion of mucus, bicarbonate, and promotes vasodilation. Boosts all other defensive factors, suppresses secretion of gastric acid. Aggressive factors contribute to ulcer or other gi disorders. Ibuprofen, aleve, aspirin decrease blood flow. Acid: develops and ulcer (must have this) Smoking: delays healing of ulcer, increases incidence of ulcers. Clarithromycin suppresses growth of h pylori. Tetracycline inhibits growth of h pylori. People are becoming more and more resistant. Differentiate between black stool from bismuth and a gi bleed prevents h pylori from adhering to gastric mucosa. Mechanism of action disrupts cell wall of h pylori, inhibit urease activity , Take massive amounts black discoloration of tongue and stool (harmless) Mechanism of action eradicate h pylori. 2-3 antibiotics together for 10-14 days to prevent resistance. Use with proton pump inhibitor or histamine2 receptor antagonist. Histamine receptor antagonist (common otc meds -- controls stomach acid)
