NATS 1670 Study Guide - Midterm Guide: Smallpox Vaccine, Drug Resistance, Microorganism
12 Dec 2017
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Document Summary
Microbes have caused the most devastating epidemics in human history. Natural microbial flora protects against more virulent microbes. The needs to be equilibrium in order for microbes and humans to stay healthy. Death of host compromises survival of infecting microbe. Infectious diseases viewed as failure of microbe to adapt to its host. Social disruption- 1 in 4 people infected. Tb vaccine stopped to be able to screen for disease. 40% of tb strains resistant to antibiotics. Antibodies kill drug susceptible microbes leaving drug resistant microbes to reproduce and multiply, replacing drug susceptible microbes. Low concentration of antibiotics provides selective advantage for resistant bacteria. Causing bacterial evolution to change and adapt remarkably fast to antibiotics. Use antibiotics at high concentration for long treatment- likely to kill susceptible and resistant microbes. Hospitals- high concentration of antibiotics spreads low concentration through hospital creating mutations. Lack of antibiotic policy in underdeveloped world. West nile virus- brought to north america.
