Pharmacology 2060A/B Study Guide - Midterm Guide: Pepperoni, Stan Marsh, Opiate
4 Jan 2017
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Metabolizes clopidogrel (pro drug) to activate as an anticoag! Um: significantly increased activity (multiple copies of gene) Decreased activity or low activity causing bone marrow suppression. Acetylates isoniazid, caffeine and various cancer causing chemicals. Glucoronidates sn-38 (anti cancer compound) rosuvasta tin. Red blood cell hemolysis following aspirin or antimalarial drugs use. Slow acetylators: neuropathy, hepatotoxicity from toxicity of isoniazid. Increased risk of diarrhea and bone marrow suppression. Increased therapeutic effect of ampicillin bleeding (life threatening) Clopiodogrel: anticoagulant (produce that requires metabolic activation by cyp2c19) Omeprazole: treat stomach ulcers inhibit clopio metabolism by inhibiting cyp2c19. Insufficient coagulation due to decrease of activated clopiodogrel. Disulfiram: treat chronic alcoholism acetaldehyde: metabolism inhibited by disulfiram. Prevent respiratory depression, coma and death from morphine overdose. Severe hangover (headache, nausea, vomiting), because acetaldehyde cannot go to acetic acid. Blood penicillin levels increase moves penicillin into lumen of.
