Philosophy 1130F/G Study Guide - Aldehyde Dehydrogenase, Caffeine, Axon Terminal
3 Oct 2014
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Administration: drug must be administered and absorbed (circulation) drug reaches site of action, exerts effects, then leaves to be metabolized to an inactive form then excreted administration, absorption, distribution, metabolism and elimination= Pharmacokinetics processes involved in the interaction of the drug with receptors=pharmacodynamics: most common methods of administration are oral, mucous membranes/skin, inhalation/pulmonary, injection. Inhalation is effective but can produce lung damage eg. huffing/bagging: when drugs are inhaled, reach brain in 5-8 seconds (faster than intravenously) Distribution of drugs injection: diffuse through pores in capillary walls orally: must be lipid soluble since there are no pores in the stomach. Concentration achieved in a time equal to 6 half lives. 4. released: binds to post-synaptic receptors, unbinds, can bind again, attach to transporter proteins to be reuptaken, or be broken down by proteins. Ach: acetylcholine and the cholinergic system: involved in breakdown: ache (acetylcholinesterase, some major effects: learning and memory (alzheimer"s) Dopamine and the dopaminergic system/ norepinephrine (noradrenaline) and noradrenergic.
