Biology 1201A Study Guide - Midterm Guide: Cleavage Furrow, Sister Chromatids, Spindle Apparatus

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Midterm answers: x-shaped chromosomes are replicated chromosomes (after s phase of mitosis). Chromosome condensation begins in prophase and is finished in metaphase. The most common phase to observe an x-shaped chromosome is in metaphase: kinetochores serve as attachment sites for the mitotic spindles (microtubules) during mitosis and meiosis. Actin makes up microfilaments, which slide past one another to create a cleavage furrow and divide one cell into two daughter cells. (cancer cells = dividing too rapidly) Mitotic spindle is made up of microtubules, microtubules are made of tubulin: cdk1= checkpoint kinase between g2 and m, cyclin b is the substrate for cdk1 (concentrations increase in g2) Cdk2= checkpoint between g1 and s, cyclin e is the substrate for cdk2 (concentrations increase in g1) Graph showed cyclin a2 (new substrate (had higher concentrations in g2, therefore, it would act as cyclin b: genome: the amount of dna in a single copy of every chromosome.

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