Biology 1001A Study Guide - Midterm Guide: Heterozygote Advantage, Founder Effect, Mendelian Inheritance
19 Dec 2017
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For cycles 1 and 2, that were tested on the october term test, focus on the following. That is, how can you inherit mutations on both homologues of chromosome 6 but give a chromosome. Meanings of gene pool, genotype frequencies, allele frequencies, genetic equilibrium. How to calculate allele frequencies, given observed genotype frequencies. How to calculate genotype frequencies expected under genetic equilibrium. Identify populations that are, or are not, at genetic equilibrium, given observed genotype frequencies. Conditions that must be met for genetic equilibrium to occur. Difference between relative vs absolute fitness and how to calculate each. How the dominance status of alleles affects the response to selection. Effect of heterozygote advantage and heterozygote disadvantage on genetic variation. Processes that reduce, remove, or maintain heritable variation in populations. Effect of non-random mating (e. g. , inbreeding) on allele frequencies and on genotype frequencies. Effects of genetic drift and gene flow on variation within a population, and variation (differentiation) between populations.
