Biology 2382B Study Guide - Midterm Guide: Kinetochore, Centrosome, Tubulin

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Microtubules often arranged so they look like they are coming from one center (microtubule organizing center mtoc) cells can have more than one mtoc: in animals, major mtoc is centrosome, plants have mtoc, but no centrosome centrosomes made of 2 centrioles made of triplet mts that form hollow cylinders and lie 90 from each other, mts that come out of mtoc don"t actually touch the centrioles, they come out of the pericentriolar matrix surrounding the centrioles. Neurons: have dendritic microtubules and the (+) end doesn"t always grow away from mtoc; axon mts have (+) end growing away though g tubulin nucleates polymerization g turc (many proteins) provide nucleating sites at the ( ) end for mt to grow away from it in pericentriolar matrix, g tubulin is involved in nucleation (works with other proteins to make g turc) g turc is at the ( ) end, then alternates as it grows away from it.

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