Biology 2382B Study Guide - Final Guide: Microtubule Organizing Center, Pericentriolar Material, Axoneme
19 Aug 2017
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General characteristics/sizes/distribution: microtubules (sections 1 and 2) Intricate network of protein filaments that extend throughout the cytoplasm. Question how is movement achieved? cellular trafficking of organelles cell migration (networks, vs ropes vs rods) Biological molecules are 3-dimensional and take up space! no empty space in a cell. 25 nm diameter, up to 100s of m long this is a much bigger length compared to most cells; they stick out like flagella: ab dimer is basic subunit . Very stable dimer; once it forms, not separated. Have polarity; one on each side: dimers are used to polymerize microtubules. First makes a protofilament when polymerizing ab ab ab ab, one side a, other side b. Dimers themselves are about 8nm, each monomer 4nm, polymerizes end to end tubulin is abundant in our cells, easy to isolate. Almost always stays as a dimer in a cell hydrolysis plays a role in polymerization.
