Biochemistry 3381A Study Guide - Midterm Guide: Triosephosphate Isomerase, Lewis Acids And Bases, Lysozyme
7 Jan 2016
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Both have heme group (porphyrin ring) which carries oxygen (called prosthetic group, added after protein is synthesized) Mb o2 makes h bond to distal his e7 (above ring), heme coordinated to 02, his f8 below ring and ring. Heme by itself is not a good 02 carrier because it can become oxidized from fe2+ to fe3+ Something to note about kd,:it"s a dissociation constant, as affinity rises, kd goes down, its less likely to dissociate, as affinity drops, kd rises, more likely to let go. Mb delivers o2 to mitochondria for aerobic respiration, plays big role in muscle cells. %bound vs [02] graph: hb sigmoidal, mb hyperbole, hemoglobin has lower affinity (higher kd) in tissue oxygen conc. (lower oxygen) compared to mb. This means it releases oxygen in the tissue after picking it up in the lungs (high oxygen conc. Mb still has higher affinity but hb is close) makes sense, then myoglobin binds it.
