Biochemistry 2280A Final: Topic 18_ Fundamentals of Metabolism

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Derek Mc Lachlin

Document Summary

Reversible reactions to counteract changes in concentration: g . T [reactants] results in products until eqm. C o u p unfavourable reaction proceed glutamate t nhy f- glutamine t hao. E. g . via an input of energy. A glutamate t atp f phosphorylated glutamate t adp phosphorglatedglutamatetnhyto-glutam. net# glutamate t nhy t atp f glutamine t adp t pi. Reactions are coupled via an enzyme the. High enenergy bond : energetically favourable coupled with is often (unfavourable) synthesis of glucose - g - phosphate rxn takes place at that bond (nothing special about bond. Phosphocreatine releases more energy than atp when hydrolyzed. 4g for whole pathway < o conversion from a to e. Still reactions in a pathway , reactions in a pathway , enzyme one rxn becomes steady state level of b. Increases flux irreversible rxns favour the product fif ersf yergiyaho. Usually ndhmeric (multiple polypeptide chains) to allosteric site changes active site. Binding pep favours a low activity conformation.