PSL201Y1 : PSL201 - Renal.docx
Document Summary
Funtions of the urinary system filter blood regulate ionic composition of plasma regulate osmolarity of plasma regulate volume of plasma regulate ph of plasma: this all causes the formation of urine. Kidneys receive a large part of cardiac output via the renal artery. Glomerular filtration is driven by the four starling forces: glomular capillary hydrostatic pressure, hydrostatic pressure inside the bowman"s capsule, the osmotic pressure of fluids in bc, the osmotic pressure in the glomerulus. Normal filtration is 125 ml/min the filtered load is the quantity of a certain solute that is filtered at the glomerulus. Gfr stays constant with 3 intrinsic mechanisms: myogenic regulation of smooth muscle in the afferent arteriole, tubuglomular feedback, mesangial cell contraction. Extrinsic mechanisms: sympathetic control of smooth muscle in the afferent and efferent arterioles. Proximal tubule is specialized to reabsorb large quantities of solutes and water, and returns it to the blood.