PCL201H1 Study Guide - Final Guide: Sparteine, Glucuronidation, Fetal Hydantoin Syndrome
7 Apr 2016
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Document Summary
Adr= a noxious and unintended drug response when a normal dose is given. Adverse drug event=unintended or undesired event occur during drug therapy. Side effect= untended drug effects observed with drug therapy (harmful and non-harmful) Toxic effects= all possible harmful drug effects with any use/dose. Adrs: all drugs have unintended effects and potential to cause adrs drugs with narrow tw more dangerous risk vs. benefit of drug therapy. Manifestation: after start/stop of treatment, after long-term use, only at certain doses/concentrations, only in susceptible individuals or only in combination with other drugs. Cox2 inhibitor (1999-2004: non-steroidal anti-inflammatory drug indicated for treatment of osteoarthritis, rheumatoid arthritis, dysmenorrhea and management of acute pain, increased risk of myocardial infarctions and stoke. Bextra (valdecoxib) has similar adr profile but dalso risk of severe skin reactions (till 2005) Terfenadine (arrhythmia due to drug interaction) -1997. Black box wanings are given to those with severe/lethal adr. Change in drug therapy may be required, not necessarily d/c.
