IMM250H1 Study Guide - Antigen Presentation, Signal Transduction, Cell Signaling
Document Summary
Restricted to cd4+ (helper) and cd8+ (killer) t lymphocytes. Antigen binding domain also contains 2 cdrs. Cdr1 and cdr2 contact mhc receptors on another cell. Generated through the same mechanism as ig diversity. Involves rag-1, rag-2, rss, all the same enzymes & p- and n- nucleotide addition. Tcr and chain domains light chain and heavy chain of ig. Tcr v j c. Tcr v d j c [ slightly more variable than ] Variable parts are essentially the same as ig"s. Shape of antigen binding site is more consistent. Functionally, tcrs only work as cell surface proteins (no secretion) Don"t actually pass the signal that turns on the t cell themselves (they have assistants) C domain region of gene is simpler only 1 c and 2 very similar c : no known functional difference. Ig stuff where binding gets better as it binds more doesn"t happen with t cells. Tcr covers cellular and humoral immunity igs just do humoral.
