HMB300H1 Study Guide - Midterm Guide: Gut Flora, Substantia Nigra, Neurodegeneration
Document Summary
Hmb300 lecture 1 food addiction and the microbiome. Change eating habit > gut microbiome changes > brain behavioural circuits change > difficult to lose weight gained. Microbiota bacteria, viruses, eukaryotes (fungi) in and on the body (most are viruses) Easier to change microbiome genes, more cells of bacteria than cells of body. Exercise and lifestyle, antibiotics, diet, hygiene can change microbiome. Can cause diabetes, inflammation, especially in brain which is sensitive to pro-inflammatory cytokines released in gut. Dysbiosis change in normal microbiota, ratios of types of bacteria affected (disbalance in gram+ and gram- bacteria changes health) Gut microbiota: mostly anaerobic (no oxygen, balance between bacteriodetes and firmicutes cause changes in health. 500-1000 species of bacteria, but in phyla: bacteriodetes, firmicutes (gram ve and gram +ve) Stomach colon, more # of bacteria, more species of bacteria. Stomach duo jeju ile colon. Ileum + colon = lactobacilli, no streptococci, many others.
