CSB430H1 Study Guide - Final Guide: Neural Stem Cell, Retinal Ganglion Cell, Sox2

• School: UTSG
• Department: Cell and Systems Biology
• Course: CSB430H1
• Professor: Vincent Tropepe

Document Summary

Neocortical stem cell | radial glial stem cell. Mge stem cells, progenitor cells in svz, vz (become gaba interneurons in cortex) Mge progenitor cells migrating, differentiating (become gaba interneurons in cortex) Pv3 (v3 neural progenitor domain of neural tube) Pmn (motor neuron progenitor domain of neural tube) Muller glial cell (active, post-lesion) (type a cells, neuroblast) (type b1 cells, nscs) (type c cells, ta cells) Pic, ser5-p rnapii, long 3" utr multiple poly-a sequences, E2f bound by rb (retinoblastoma) cyclins + cdks off. Notch pathway on (rbpj(kappa) tf turns on hes1 gene) Foxa2 (high), arx, markers of progenitors (sox2, pax6) Otx2 promotes da cell fate in floor plate. Otx2 restricts da cell fate outside floor plate. Nurr1, lmx1a, lmx1b, pitx3 (maintenance of cell fate) Th gene, da neurotransmitter release, da transporter (dat)