BCH210H1 Study Guide - Fall 2018, Comprehensive Midterm Notes - Protein, Protein Structure, Alpha Helix
12 Oct 2018
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Course
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BCH210H1
MIDTERM EXAM
STUDY GUIDE
Fall 2018
BCH210 - Lecture 1
Red Blood cells
● Hemoglobin
○ Protein
○ Red colour cause by the Fe heme complex
○ Tetramer: 2 alpha and two beta polypeptide chains
Sickle Cell Anemia
● Signal change in amino acid (beta change)
● Caused by the replacement of the beta subunit from Val to Glu
● Hemoglobin S (Hb S) forms a long forms a long polymer → changes the RBC’s shape
Proteins
● Polymers of amino acids
○ Amino acids linked by peptide bonds
● Amino acids determine the structure of the protein folding
● Key to biological functions → work as enzymes
● Encoded by genes → mutation in genes causes mutated protein → lead to diseases
Molecules of Life
● Proteins
● Water
● Ions
● Vitamins
● Sugar
● Lipids
● DNA & RNA
H2O
● Polar
● Important solvent & reactant biological reaction
● Many protein are water soluble
● Responsible for molecular structure
○ Certain enzymes and structure are produced in water
Forces
● Hydrophobic (scared of water)
● Ionic interactions (opposite charges)
● Hydrogen bonds (specific - based in DNA use H bonds)
● Van der Waals (contact)
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find more resources at oneclass.com
Hydrophobic effect
● Effects the shape of the protein structure
● H2O as a solvent
○ Hydrophobic (non polar) amino acids would be interior part of the globular protein
○ Hydrophilic (polar) amino acid would be on the exterior part of the globular
protein
ATP
● Contains:
○ Tri phosphate group
○ Sugar ribose
○ Adenine base
● C and N bond between the base and ribose
produces a nucleoside (adenosine)
● Metabolism is required a person to make and use ATP at their own weight
NADPH
● Starts off as ATP
● Has nicotinamide
ATP production pathway
● Best source of production for ATP: carbohydrates (SUGAR)
● Glucose enters the pathway at the very beginning while fats and protein can enter later
on in the cycle
Draw the ATP cycle
find more resources at oneclass.com
find more resources at oneclass.com
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BCH210H1 Full Course Notes
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