PSY 1101 Study Guide - Final Guide: Methylenetetrahydrofolate Reductase, Glycine Cleavage System, Serine Hydroxymethyltransferase

• School: University of Ottawa
• Department: Psychology
• Course: PSY 1101
• Professor: Najwa Haddad

Document Summary

Required for do novo synthesis of purines and thymidylate, as well as methionine synthesis. Oxidation levels of c1 groups carried by thf. The purine ring is derived from many molecules. N3 + n9 amine group from glutamine. Imp nucleotide of the base hypoxanthine. Pyrophosphoryl group transferred directly from atp to r5p c1-oh group. Prpp is common to both purine and pyrimidine synthesis. Once, prpp is activated, the next 6 steps are analogous reactions. Each step requires the activation of a carbon-bound oxygen atom by phosphorylation, followed by the displacement of a phosphoryl group by ammonia or an amine group acting as a nucleophile (nu) Step 2: acquisition of purine atom n9. Step 3: acquisition of purine atoms c4, c5, and n7. Step 4: acquisition of purine atom c8. Step 5: acquisition of purine atom n3. Step 6: formation of purine imidazole ring. Competition for a limited resource leads to compartmentalization, substrate channeling and enzyme-enzyme interactions.