PHA 4107 Study Guide - Comprehensive Final Exam Guide - Cell Surface Receptor, Skeletal Muscle, Neurotransmitter
20 Nov 2018
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Document Summary
Study of the factors determining the amount of drug at the receptor site. Study of the mechanisms by which drugs produce their biological effects. Movement across cell membranes: membrane function as a barrier to the free movement of drug into (and out of) the bloodstream, ability to cross membrane determine where and how long a drug will be present in the body. The cell membrane consists primarily of a double layer of phospholipid molecules. The larger globular structures represent protein molecules imbedded in the lipid layer. Passage of drugs across membranes: 3 ways to cross a membrane, channel and pores, transport systems, penetration of the membrane. Transport systems: large protein-mediated movement of drugs across a membrane, structure-specific/selective, most drugs absorbed via transport share similarity with endogenous compounds i. e. vitamins. In some cases, no expenditure of energy is necessary and a drug moves with a concentration gradient (passive transport)
