MIC 4124 Study Guide - Quiz Guide: Necrotizing Fasciitis, Arthralgia, Pyelonephritis

• School: University of Ottawa
• Department: Microbiology and Immunology
• Course: MIC 4124
• Professor: Thien Fah Mah

Document Summary

Physiology: review the pathophysiology, risk factors, signs/symptoms, common causes and potential complications associated with fever. Pathophysiology: exogenous: microorganisms and toxins induce formation and release of endogenous pyrogens (which then causes fever, endogenous. Polypeptides produced by host cell macrophages, monocytes and other cells in response to damaged tissue. Il-1 & il-1 , tnf , il-6, cnf and ifn- . Their release causes symptoms such as myalgias & arthralgias. Heat-dissipating phase: peripheral vasodilation to promote heat loss. Skin feels hot, flushing sweating (cholinergic) headache. Heat-generating phase: peripheral vasoconstriction to prevent heat loss . Causes of fever: an increase in body temperature may be idiopathic or the result of infectious and other pathologic processes, systemic response to certain drugs, and vigorous activity. Antigen-antibody reactions drug fevers (drug: integument cellulitis, necrotizing fasciitis induced hyperthermia) Hyperthermia: an uncontrolled elevation in body temperature without elevation of the hypothalamic set point.