HSS 3106 Study Guide - Midterm Guide: Vasoconstriction, Azithromycin, Clindamycin
Document Summary
Treat post-operative infections, not often used because more expensive. Block steps in pathway of folic acid (needed to synthesize nucleic acid)- Enhanced with trimethoprim (antibiotic, interferes with tetrahydrofolic acid production. Inhibit formation of petoglycan in the cell wall. Bind to 30s subunit of bacterial ribosomes to stop protein synthesis. Common: nausea, vomiting, diarrhea, fever, stomatitis (lip and mouth inflammation) Common: nausea, vomiting, black tongue (buildup of bacteria to form papillae projections) Common: pain, nausea, vomiting, glossitis (tongue inflammation), abdominal pain. Serious: ototoxicity (to the ear), nephrotoxicity, can cause superinfection (new infection superimposed on original infection) from prolonged use. Pregnancy, with other penicillins (decrease effects), increase warfarin effects, increased ototoxicity risk with ethacrynic acid. Uti"s, prostatitis, gonorrhea, pneumonia, infections of bones and joints, anthrax (bacteria) Inhibit bacterial protein synthesis by binding bacterial ribosomes. Bacteriostatic at normal doses (stops reproduction); bactericidal at high doses (kill) Interfere with dna gyrase (enzyme bacteria needs for.