BPS 3101 Study Guide - Midterm Guide: Transposable Element, Retrotransposon, Retrovirus

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peargoldfish669

16 Oct 2011

School

University of Ottawa

Department

Biopharmaceutical sciences

Course

BPS 3101

Professor

Linda Bonen

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Document Summary

Genomic midterm for part iii of course (important concepts) In tandem arrays (eg. rrna genes, globin genes) Dispersed (ex. actin genes on different chromosomes) Microsatellites < 5 bp, clusters usually <150 bp (also known as ssr = simple sequence repeat). They can occur within genes and may be detrimental (ex. Minisatellites <25 bp, clusters up to 20 kb. Dna with biased base composition migrates as satellite bands on buoyant density gradients. Tandemly repeated sequences (centromeres, telomeres, spacers, etc. ) Most genes are in non-repetitive dna regions but low-to-mid repetitive dna fraction includes multi-gene families. Usually as organisms increase in complexity, they have more dna. C value paradox: in certain cases, lack of correlation between morphological complexity and genome size. Numbers and length of introns vary among eukaryotes. Synteny = conserved gene order among organisms. Also, human gene set may be considerably smaller than its protein set because of alternative splicing.

Related Questions

Please answer everything

1. Which of the following choices most accurately describes the proteins that form the linker histones of the chromatosome?

A) H2A, H2B, H3, H4

B) H2A, H1t, H5, H3

C) H5, H1a-e, H1t, H10

D) H3A, H1, H4A, H5

2. Which of the followings is not an example of randomly repeated DNA?

A) Minisatellites

B) Alphoid DNA in Centromere

C) Retrotransposons

D) Microsatellites

3) Which of the followings is not found in the human genome?

A) Long interspersed nuclear repeat

B) Short interspersed nuclear repeat

C) Insertional sequence

D) Long terminal repeat

4) Which of the following is not true?

A) Major portion of human genome is placed by repetitive sequences

B) The yeast genome is very compact

C) The higher eukaryotic organisms always have more complex genome

D) The genes make up only a small part of the human genome

5) What does the functional analysis of genome suggest the researchers about eukaryotic organisms?

A) All eukaryotic organisms have the same numbers of genes in each functional category.

B) All eukaryotic organisms have approximately the same number of genes.

C) Complex organisms have a larger portion of unknown genes

D) Complex organisms have greater numbers of genes in each functional category

E) Simpler organisms contain many fewer types of gene when compared to complex organisms

When total DNA from the kangaroo rat (Dipodomys ordii) is analyzed by equilibium density-gradient centrifugation, a fraction of the DNA forms a distinct satellite band

in the gradient. This satellite DNA contains a highly repeated DNA sequence that can be isolated from the gradient free of other DNA sequences. Many such highly repetitive DNA sequences are located in regions of heterochromatin adjacent to the centromeres of chromosomes (âcentromeric heterochromatinâ). How could a researcher determine where the satellite DNA sequence is located in the chromosomes of the kangaroo rat?

1.A gene-encoding sequence is an example of which type of DNAsequence in eukaryotes?

Select one:

a. Moderately repetitive DNA

b. Short interspersed elements

c. Highly repetitive DNA

d. Unique-sequence DNA

e. Long interspersed elements

Telomeres exist to help with the _________ of the ends ofeukaryotic chromosomes.

Select one:

a. replication

b. metabolism

c. translation

d. transcription

e. destabilization

1Which of the following has repetitive DNA andheterochromatin?

Select one:

a. Mitochondria

b. Telomere

c. Centromere

d. Chloroplast

e. a and b

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BPS 3101 Study Guide - Midterm Guide: Transposable Element, Retrotransposon, Retrovirus

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