HLSC 3800U Study Guide - Midterm Guide: Cancer Research Uk, Nicotine Patch, Smoking Cessation
Critical Appraisal of Statistics in Health Science
HLSC 3800U
Question #8. (8 marks) Lecture Week 6, Lecture 2
Effectiveness of a nicotine patch in helping people stop smoking: results of a randomised trial in general practice.
Imperial Cancer Research Fund General Practice Research Group. https://www.ncbi.nlm.nih.gov/pubmed/8518571
OBJECTIVE: To assess the effectiveness of 12 weeks treatment with a 24-hour transdermal nicotine patch in helping heavy
smokers to stop smoking.
DESIGN: Double blind placebo controlled randomized trial with a 2 x 2 factorial design.
SUBJECTS: 1686 heavy smokers aged 25-64 (mean cigarette consumption 24/day; mean duration of smoking 25 years).
RESULTS: Cessation was confirmed in 163 patients (19.4%) using the nicotine patch and 99 patients (11.7%) using the placebo
patch (difference 7.6% (95% confidence interval 4.2% to 11.1%); p < 0.0001).
CONCLUSION: Nicotine patches are effective in a general practice setting with nursing support, but the extent to which this
effect is sustained cannot be assessed until the results of longer term follow up are known.
Iterestig that No Authors ere reported for this study so, you, as the statistician, need to satisfy
yourself that what they are saying is actual and factual.
“ice they state that the icotie patch is effectie, the it is assued that the Patch ould result i
greater smoking cessation. This being the case, then test the claim at 95% confidence that a larger
proportion of smokers quit smoking using the patch than those not using the patch.
From the Results section;
a) State the Null and Alternative Hypotheses (1)
b) Prepare the PDF and State the Decision / Rejection Rule (1,1)
c) Conduct the test (3)
d) State the Decision and Interpretation (1, 1)
Cessation
Method
Number of
Participants
Number
Quit
Percentage
Quit
Patch
840
163
19.4%
Placebo
846
99
11.7%
1686
262
15.5%
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Document Summary
Question #8. (8 marks) lecture week 6, lecture 2. Effectiveness of a nicotine patch in helping people stop smoking: results of a randomised trial in general practice. Imperial cancer research fund general practice research group. https://www. ncbi. nlm. nih. gov/pubmed/8518571. Objective: to assess the effectiveness of 12 weeks treatment with a 24-hour transdermal nicotine patch in helping heavy smokers to stop smoking. Design: double blind placebo controlled randomized trial with a 2 x 2 factorial design. Subjects: 1686 heavy smokers aged 25-64 (mean cigarette consumption 24/day; mean duration of smoking 25 years). Results: cessation was confirmed in 163 patients (19. 4%) using the nicotine patch and 99 patients (11. 7%) using the placebo patch (difference 7. 6% (95% confidence interval 4. 2% to 11. 1%); p < 0. 0001). Conclusion: nicotine patches are effective in a general practice setting with nursing support, but the extent to which this effect is sustained cannot be assessed until the results of longer term follow up are known.
