HLSC 2110U Study Guide - Midterm Guide: Phosphoribosyl Pyrophosphate, Oligonucleotide, Hyperuricemia
24 Apr 2019
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One or more phosphates connected to a nucleoside (product pentose sugar and nitrogenous base) Serve as carriers in the synthesis of some carbs, fats, and conjugated proteins. Atoms of purine ring come from amino acids, carbon dioxide, and nitrogen. Compounds donate carbon and nitrogen to ribose 5-phosphate. In the synthesis, there are intermediary products like: Ribonucleases and deoxyribonucleases hydrolyze dietary rna and dna to oligonucleotides. Oligonucleotides are hydrolyzed by pancreatic phosphodiesterases which makes a mix of 3" and 5"-mononucleotides. In intestine mucosal cells, family of nucleotidases removes phosphate groups hydrolytically which release nucleosides. Dietary purine bases are not used they are converted to uric acid in intestinal mucosal cells. Uric acid enters blood and is excreted in urine. High levels of uric acid in blood hyperuricemia. Leads to deposits of crystals in joints causing inflammation. Tophi (crystals) can be deposited in soft tissues too. May be a secondary issue that arises because of kidneys, medications, or exposure to lead.
