PCTH 201 Study Guide - Midterm Guide: Proton-Pump Inhibitor, H2 Antagonist, Medical Cannabis
31 Oct 2017
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May confer antidepressant and anxiolytic effects of serotonin receptor. Interactions with multiple receptors as both agonist and antagonist. Histamine receptors (all gpcrs g-protein coupled receptor): Stimulation of gastric acid release from parietal cells. Receptor is structurally similar to muscarinic receptors. May produce side effects related to inhibition of digest ) H 2 antagonists can completely block basal acid release, but food-related triggers antagonism by direct stimulation of parietal cell. Temporary relief overwhelmed by food-triggered acid release. 18-24 hours to make new proton pumps (one-daily therapy) Pyresis (fever) anti-inflammatory analgesic ( ) antipyretic ( ) Numerous potential side effects pgs everywhere in body. E. g. increase ulcer risk due to inhibition of pg-mediated mucus secretion. 50% reduction in colon cancer risk when taken >5 years. Not anti-inflammatory not an nsaid (can be used as an adjunct with nsaids) At high doses of acetaminophen, metabolic pathways will get saturated. Induction of cyp450 metabolism pathway creates reactive/toxic intermediate ( napqi )
