BIOL484 Study Guide - Midterm Guide: Polytene Chromosome, Endoreduplication, Trophoblast
6 Apr 2018
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There was already an indication that genes paralleled chromosomes. If we could somehow change or manipulate the manner in which chromosomes behaved, then we should see a corresponding and change in inheritance patterns (genes). So that"s what bridges did - although he wasn"t directly manipulating chromosomes and forcing them to behave differently, he found a situation where they do behave differently. When chromosome behaviour in meiosis was perturbed through xx+y or x + xy pairing, there was a corresponding and exact parallel in inheritance patterns of x-linked mutants. His cytology of exceptional progeny confirmed that the changed inheritance patterns were associated with changes in the chromosome complement. In other words, when the parallel between x-linked genes and chromosome constitution was maintained, even the loudest critics had to accept that genes were on chromosomes. The recombination frequency between two genes is equal to the proportion of offspring in which a recombination event occurred between the two genes during meiosis.
