BIOL239 Study Guide - Quiz Guide: Tumor Suppressor Gene, Ovarian Cancer, G1 Phase

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scarletbee935

8 Apr 2017

School

University of Waterloo

Department

Biology

Course

BIOL239

Professor

Christine Dupont

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Document Summary

Why is the incidence of cancer increasing: increasing new cases because we are living longer, it"s a disease of aging so no surprise. Disparity in expected and observed cancer deaths: lines diverge as people survive with cancer because of diagnosing early, treatment and fewer carcinogens. Its multifaceted, not a single disease, with each person having a different cancer with different random mutation. So is cancer not infectious: can metastasize and are malignant, little genetic diversity in devils, and the face tumor is passed on through biting and playing and mating (infectious tumor) What are the genes cancer arises from: cancer arises when controls over cell division no longer function properly, diploid organisms have two copies of these, tumor-supressor genes. Involved in cell cycle control act recessively: p53 and rb (also called gene tp53 and prb) If present p53 prevents cell from going to s phase (tumor suppression by denying formation). Describe the inheritance of p53: right mutations in wrong.

Related Questions

I am an ESL student. I am doing a research on a new disease. Following is the introduction of our research. It is really important, I will use it to apply for approval and funding.
Because I am an ESL so mistakes are unavoidable. Could you please help me by checking and correcting my grammar, changing some words/sentences and make it more native and smooth ?

"Micronutrient deficiencies can lead to many severe diseases such as anemia, pellagra, osteomalacia or impaired cognitive development. There are more than 2 billion people worldwide affected by micronutrient malnutrition. In Vietnam, regardless of economic growth improvements in recent years, micronutrient deficiencies still remain the major public health problem. Especially, the issue is even more detrimental in ethnic minorities due to their poverty, backward eating habit and insufficient nutritional knowledge.

From April 2011, an idiopathic disease called inflammatory palmoplantar hyperkeratosis (IPPH) syndrome has caused 20 deaths among 300 hospitalized patients in Ba To, a rural district of Quang Ngai province in central Vietnam. Ba To is a remote mountainous district highly populated by ethnic minorities whose main occupations are farming. Most of households had been continuously consuming moldy rice stored in poor conditions from previous harvests. Of the cases known to have died, 62.8% of patients were admitted with malnutrition and wasting syndrome. We hypothesized that micronutrient deficiencies are the risk factors of high incidence of IPPH syndrome in ethnic minorities. Therefore, we aim to study the micronutrient status and the adequacy of micronutrient intake in ethnic minorities. This study also investigates the association of socioeconomic status, lifestyle factors and living environment of ethnic minorities with their micronutrient malnutrition. Subsequently, a research-based community intervention will be conducted to prevent and control outbreak of IPPH syndrome in Ba To district."

blackferret405

Q49. Which of the following is NOT true?

If a genetic disease reduces fertility and the allele thatcauses the disease offers no other advantage, the allele willlikely eventually disappear, due to natural selection.

Natural selection does not favor individuals who are homozygousfor the sickle-cell allele, because these individuals typically diebefore they are old enough to reproduce.

Individuals who are heterozygous HbA/HbS areprotected from malaria, and this is why sickle-cell diseasepersists in wetter, mosquito-prone regions in Africa.

In regions where malaria does not occur, individuals who areheterozygous HbA/HbS have a fitness advantageover those who are homozygous for the normal hemoglobin allele(HbA).

Q50. AFTER malaria is cured, the frequency of the HbSallele should decrease in regions with lots of mosquitoesbecause:

People will no longer die from sickle-cell disease in theseregions.

Having one copy of the HbS allele will no longer beadvantageous in these regions.

Natural selection will no longer act on the HbS alleleat all in these regions.

All alleles associated with genetic diseases eventuallydisappear.

Q52. If the frequency ofthe HbS allele is 0.4 in a population, what is thefrequency of the HbAallele (assuming this is atwo-allele system)?

Q53. Which of the following would be sufficient for theHardy-Weinberg equation to accurately predict genotype frequenciesfrom allele frequencies?

p + q = 1

The population is not evolving due to natural selection.

The population is not evolving due to any of the conditions thatdisrupt Hardy-Weinberg equilibrium.

The population is infinitely large.

Q54. In a village, if the proportion of individuals who havesickle-cell disease is 0.25, and the population is assumed to be atHardy-Weinberg equilibrium, what is the expected frequency of theHbS allele? (Hint: What is the genotype of people withsickle-cell disease, and how is that genotype represented in theHardy-Weinberg equation?)

0.1250.250.50.75

Q55. In the same village, what proportion of the populationshould be heterozygous HbA/HbS, according to theHardy-Weinberg equation?

Use the following passage to answer the nextthree questions.

It has been hypothesized that people who are heterozygous forthe allele that causes the deadly genetic condition cystic fibrosis(which, among other symptoms, reduces fertility) are more resistantto the deadly disease tuberculosis.

Q56. If the cystic fibrosis allele protects against tuberculosisthe same way the sickle-cell allele protects against malaria, thenwhich of the following should be true of a comparison betweenregions with and without tuberculosis?

Cystic fibrosis deaths should be more common in regions withtuberculosis.

Cystic fibrosis deaths should be less common in regions withtuberculosis.

Cystic fibrosis deaths should be equally common in both types ofregions.

Regional differences in the cystic fibrosis death rate should bepurely random and unpredictable.

Q57. A person who is heterozygous for the cystic fibrosis allelemoves to a small, isolated community where no one previouslycarried the allele. If the cystic fibrosis allele protects againsttuberculosis the same way the sickle-cell allele protects againstmalaria, what should happen to the frequency of the cystic fibrosisallele in the community over time, and why?

The cystic fibrosis allele should disappear from the population,because a single individual with the allele is not enough for it toproliferate.

The cystic fibrosis allele should increase to a relatively highfrequency, because heterozygotes with the allele will be morelikely to survive than others.

The cystic fibrosis allele should become fixed in thepopulation, due to genetic drift.

The cystic fibrosis allele should either disappear or increasein frequency, depending on chance as well as on tuberculosisprevalence and death rate.

Use the following additional passage to answer the nextquestion.

Suppose you travel to the future, to a time when neithercystic fibrosis nor tuberculosis have caused any deaths for manygenerations. In all of these future populations, thecystic fibrosis allele still exists at a low frequency.

Q58. You visit a huge city with millions of people. If you wereto start sampling the cystic fibrosis allele from one generation tothe next, what should happen to its frequency over the next fewgenerations, and why?

The allele frequency should change a lot from one generation tothe next due to random genetic drift.

The allele frequency should not change much from one generationto the next because the population is large.

The allele frequency should steadily increase due to naturalselection.

The allele frequency should steadily decrease due to naturalselection.

amaranthherring501

Case Study

Skolnikland is in Eastern Africa, with a population of 30 million people. The country has a plains region, a hill region, and a region with high mountains. It has a number of ecosystems. The plains are dry for much of the year, there is some rainforest, and the rest of the country includes both hills and mountains. There are two seasons of heavy rainfall.

The citizens come from several ethnic groups that tend to live in their own regions and speak different languages. The ethnic groups largely follow one of three different religions. The large cities are mixed ethnically. One ethnic group is economically and socially very dominant. The people from this group live in the capital and most of the large cities. The national language is the language of this dominant ethnic group.

According to World Bank criteria, Skolnikland is among the poorest countries in the world. The economy has been growing at about 4% per year on average over the last decade, but the economy had very slow economic growth in the decades prior to that. The richest 10% of the population controls 80% of the national income.

About 80% of the people live in rural areas and 20% in urban areas. The number of people living in urban areas has been growing recently at an increasing pace. Most people earn their livelihood in agriculture but there is an increasing garment manufacturing industry in the two largest cities. There are also a number of mining industries. In addition, other export industries are beginning to grow, mostly focused on the export of commodities to China.

The total fertility rate is about 4.5 but it has been declining slowly over the last two decades, from over 6. There is an almost equal number of men and women in the population. Infant mortality is about 90 per 1,000 live births. Maternal mortality is about 500 per 100,000 live births. Thirty-five percent of the children are underweight for age.

The adult literacy rate is about 40%. The educational enrollment rate, especially for girls at the primary and secondary levels, has been growing slowly, but steadily. Most recently, this rate has been growing at an increasing pace and about 75% of the girls now attend school regularly, although many of them are of very low quality.

Only about 50% of citizens have access to safe water. Only about 30% have access to sanitary disposal of human waste.

HIV prevalence is 7% of the adult population. The number of new HIV cases annually has begun to plateau. About half of the people eligible for treatment for HIV are on treatment. Malaria is rampant in the plains.

Investments in the road system have been growing at a solid pace in the last decade and the use of private automobiles has begun recently to increase more rapidly.

Skolnikland has a pluralistic health system that is made up of public and private institutions, publicly financed providers, licensed private providers, unlicensed medical practitioners, and traditional healers. There is no health insurance, except for some free services for the poor in the few publicly financed hospitals, which the better off people do not attend. The health system is not very effective or efficient and is generally of low quality. The HIV, TB, and malaria programs are not effective or efficient and they are just beginning to adopt paradigms for services that follow global best practices.

QUESTION 26

What is a DALY?