PATH 3610 Study Guide - Final Guide: Immunotherapy, Vasoactivity, Vellus Hair

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Doug Goff

Document Summary

Cause injury since they are very reactive due to their single unpaired electron on their outer shell. Three reactions to cell injury by free radicals are: Lipid peroxidation - react with double bonds in unsaturated lipids in membranes. Cross-linking/changes in protein - degrade proteins causing dysfunction or inactivity. Dna damage - produce single strand breaks in dna when react with thymine. In five points, summarize the ultrastructural changes of reversible cell injury, which lead to these recognizable microscopic changes: Cellular swelling due to failure of energy- dependent ion pumps in the plasma membrane. Infarcts (necrosis due to lack of blood supply) Microscopic: fragmented or lysed cells, which stain pink, and have an inflammatory border. Microscopic: shadowy outlines of necrotic fat cells with calcium deposits, surrounded by inflammatory response. Inflammatory response to fat destruction due to release of pancreatic lipases into peritoneal cavity. Describe lethal and non-lethal cell injury, and apoptosis.